Columbia enjoys a diversified economy, with the major employers in the area being South Carolina state government, the Palmetto Health hospital system, Blue Cross Blue Shield of SC, Palmetto GBA, and the University of South Carolina. Neighboring Cayce is home to the headquarters of SCANA, a Fortune 500 company which supplies energy to parts of the Carolinas and Georgia. Other major employers in the Columbia area include Fort Jackson, the U.S. Army's 2nd largest training installation behind Fort Bragg, Richland School District One, Humana/TriCare, and the United Parcel Service, which operates its Southeastern Regional Hub at the Columbia Metropolitan Airport. Major manufacturers such as Square D, CMC Steel, Spirax Sarco, Michelin, International Paper, Pirelli Cables, Honeywell, Westinghouse Electric, Harsco Track Tech, Trane, Intertape Polymer Group, Union Switch & Signal, Solectron, and Bose Corporation Technology have facilities in Columbia.
Several companies have their global, continental, or national headquarters in Columbia, including Collexis Holdings, Inc., a software development company; Colonial Supplemental Insurance, the second-largest supplemental insurance company in the nation; Holopack International, a German-owned company that provides a wide range of services to the pharmaceutical industry; First Citizens bank, the second largest state-based bank; South Carolina Bank and Trust; Spectrum Medical, an international medical software company; Wilbur Smith Associates, a full-service transportation and infrastructure consulting firm; and Nelson Mullins, a major national law firm.
Columbia's economy is set to be revolutionized within the next few years with the establishment of the University of South Carolina's research campus, dubbed Innovista. Research will be aimed at the emerging technologies and intellectual clusters: biomedical, environmental, nanotechnology, and future fuels. Columbia Info Source
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